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All Journal Majalah Kedokteran Sriwijaya Sriwijaya Journal of Ophthalmology Ophthalmologica Indonesiana
Devi Azri Wahyuni
Department Of Ophthalmology, Faculty Of Medicine, Universitas Sriwijaya Mohammad Hoesin Hospital, Palembang, South Sumatera
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Physics Public Health

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Journal : Majalah Kedokteran Sriwijaya

 1 
Karakteristik Klinis Kelainan Mata pada Pasien dengan Massa Intrakranial di RSUP Dr. Moh. Hoesin Palembang Periode1 Januari 2013-31 Desember 2015 Yuventius Odie Devanand; Devi Azri Wahyuni; Nyayu Fauziah Zen
Majalah Kedokteran Sriwijaya Vol 49, No 2 (2017): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v49i2.8530

Abstract

Massa intrakranial merupakan suatu lesi ekspansif yang dapat meluas secara volume dan menggantikan struktur normal di dalam ruang tengkorak (intrakranial). Massa intrakranial menyebabkan timbulnya berbagai tanda dan gejala umum ataupun lokal dari sistem saraf tergantung dari lokasi dan tingkat pertumbuhan massa. Gejala dan tanda pada mata akibat massa intrakranial meliputi kehilangan penglihatan, penglihatan ganda,palsi saraf kranial, abnormalitas pada pupil, proptosis, dan defekpada kepala nervus optikus. Penelitian ini bertujuan memberikan informasi mengenai karakteristik klinis kelainan mata yang terjadi akibat massa intrakranial sehingga memudahkan penegakan diagnosis dan penentuan tatalaksana.Penelitian ini menggunakan data sekunder berupa rekam medik di Instalasi Rekam Medik RSUP Dr. Mohammad Hoesin Palembang.Didapat 143 pasien massa intrakranial periode 1 Januari 2013-31 Desember 2015, namun hanya 73 pasien yang  memenuhi kriteria inklusi untuk dijadikan sampel penelitian. Penurunan visus merupakan kelainan mata terbanyak. Mayoritas pasien memiliki visus buruk. Kelainan kedudukan bola mata terbanyak adalah eksotropia.Kelainan gerak mata terbanyak disebabkan oleh parese N. III.Defek lapang pandang terbanyak adalah hemianopsia bitemporal.Kelainan jaringan orbito-okular terbanyak adalah ptosis.Kelainan gambaran papil terbanyak adalah papiledema.
CORRELATION OF Hba1c LEVELS WITH PUPILLARY RESPONSE TO APRACLONIDINE 0,5% EYE DROPS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Devi Azri Wahyuni; Nafila Mahida Sukmono; Erial Bahar
Majalah Kedokteran Sriwijaya Vol 52, No 3 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i3.12503

Abstract

Pupillary reflex abnormalities can result from disorders of the innervation or iris structure of the eye. In people with diabetes mellitus, the pupil size becomes smaller than normal due to neuropathy in innocent sympathetic innervation of the pupil. This neuropathy is associated as a manifestation of uncontrolled diabetes complications. Pupillary response is associated as a general indication of autonomic neuropathy disorders in diabetes mellitus patients. Apraclonidine as an ophthalmic sympathomimetic agent can cause mydriasis, which is likely to identify pupillary sympathetic denervation in type 2 diabetes mellitus patients. This study aimed to find out the correlation between HbA1c levels and pupillary response to 0.5% Apraclonidine eye drops in diabetes mellitus type 2 patients at Mohammad Hoesin Hospital Palembang. Observational research with a correlation test design to investigate the correlation of HbA1c levels with pupillary response to apraclonidine 0.5% eye drops in patients with type 2 diabetes mellitus has been conducted from March to May 2019. The study sample met the inclusion and exclusion criteria of 31 diabetics mellitus type 2 with HbA1c level> 6.5% in the Eye clinic at the Mohammad Hoesin Palembang hospital. In this study 31 patients with type 2 diabetes mellitus with HbA1c levels >6.5 mg% were obtained. The average HbA1c level was 9.5 ± 1.4 mg%, which ranged from 7.6 - 12.6 mg%. The glycemic status of the patients in this study were all (100.0%) in an uncontrolled condition (HbA1c> 7.5 mg%). The estimated duration of diabetes mellitus is 2.7 ± 1.8 years, with a minimum value of 1 year and the largest being 8 years. The average change in pupillary diameter before - after dropping 0.5% apraclonidine was 1.16 ± 1.06 mm, ranging from 0 - 4 mm. There were 9 (29.0%) eyes that did not show any changes. Significant enlargement of pupillary size after dropping 0.5% apraclonidine (p = 0,000). This change in pupil size correlated with the estimated duration of diabetes mellitus (r = 0.436, p = 0.014) and HbA1c levels (r = 0.492, p = 0.005). Pupil size after using 0.5% apraclonidine has a distribution value of 4 (3-6) mm can be interpreted that there are subjects who have no change, but there are patients who have pupils dilated to 6 mm.
CORRELATION BETWEEN ETHAMBUTOL THERAPY DURATION AND ZINC SERUM LEVEL WITH COLOUR VISION DEFICIENCY IN TUBERCULOSIS PATIENTS Devi Azri Wahyuni; Mira Retna Tetiana; Mgs Irsan Saleh; Ahmad Rasyid
Majalah Kedokteran Sriwijaya Vol 52, No 2 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i2.11975

Abstract

Tuberculosis is one of the most common disease in Indonesia. Ethambutol is one of the main regiment therapy for patient with tuberculosis. Duration of ethambutol therapy depends on what category of tuberculosis patient. Ethambutol intake can cause optic neuropathy with colour vision deficiency as an early symptom. Ethambutol therapy can also cause decrease of zinc serum level and it is cause by zinc chelate that can be found in ethambutol. The purpose of this study was to determine the correlation between duration of ethambutol therapy and zinc serum level with colour vision deficiency which examined with Farnsworth Munsell 100 Hue in tuberculosis patients. This is an observational explorative study. Colour vision is xamined with Farnsworth Munsell 100 Hue and zin serum level is detected by blood sample. Data was analyzed by correlation study. Correlation statistic between ethambutol therapy duration with colur vision using Spearman coreelation study found that r = 0,5 and p = 0,00, whereas in correlation between zinc serum level with colour vision found that r = 1,68 and p = 0,32. There is significant correlation and positive direction between ethambutol therapy duration with colour vision deficiency. Even though there is no significant correlation between zinc serum level with colour vision deficiency, there is a strong correlation.
COMPARISON OF COPPER LEVEL AND COLOR VISION IN PULMONARY TUBERCULOSIS PATIENTS BEFORE AND AFTER ETHAMBUTOL TREATMENT IN CATEGORY I AND II Devi Azri Wahyuni; Febria Restissa; Ahmad Rasyid; Erial Bahar
Majalah Kedokteran Sriwijaya Vol 52, No 2 (2020): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v52i2.11969

Abstract

Copper as a metal chelator in ethambutol may interfere oxidative phosphorylation and mitochondrial function that are useful in the formation of ATP, so that long-term damage can cause apoptosis and interfere color vision. This study aims to determine the correlation between duration of ethambutol and copper levels in serum with color vision disorder examined with Farnsworth Munsell 100 Hue (FM100) in patients with tuberculosis. This study was an explorative observation of 20 samples during November 2017 - January 2018 period. Comparative analysis using independent t-test, paired t-test, Wilcoxon test and Mann-Whitney test, while correlation analysis using Spearman's test and Pearson's test. There was a significant difference of FM100value before and after in category I (p=0.000) with increase of total error value 11.80+5.31 or category II (p=0.000) with increase of total error value 15.00+7.41. There was significant difference of Cu2+  level before and after in category I (p=0.005) with decrease of  Cu2+ level 15.57+5.04 mg/dL or category II (p=0.005) with decrease of  Cu2+ level 31.66+7.35 mg/dL. The duration of Ethambutol was related to changes in color vision examined with FM100.
Co-Authors Agus Nugroho Ahmad Rasyid Ahmad Rasyid Erial Bahar Febria Restissa Febria Restissa Frida Lestari Mgs Irsan Saleh Mira Retna Tetiana Nafila Mahida Sukmono Nyayu Fauziah Zen Yuventius Odie Devanand Zahratul Riadho Farid